Cyclobenzaprine Flexeril Side Effects & Interactions
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). If any of these effects last or get worse, tell your doctor or pharmacist promptly. Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Ask your doctor when to start or stop taking this medication.
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It is unknown if Flexeril passes into breast milk or if it could harm a nursing baby. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Talk to your doctor if you are using marijuana (cannabis). Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. HealthLinkBC Files are easy-to-understand fact sheets on a range of public health and safety topics including disease prevention and immunizations.
Interactions that can increase the effect of cyclobenzaprine
In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Although rare, deaths may occur from overdosage with FLEXERIL.
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The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Avoid driving or hazardous activity until you know how cyclobenzaprine will affect you. It may not be safe to breast-feed while using this medicine. Do not use cyclobenzaprine if you have taken an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, or tranylcypromine.
Other uses for this medicine
Do not start, stop, or change the dose of any drug your child takes without checking with the doctor. Flexeril is a prescription medication used to relax muscles and relieve pain due to muscle spasms. Flexeril belongs to a class of drugs called muscle relaxants, which help by preventing muscle spasms without affecting overall muscle control and function. Cyclobenzaprine (Flexeril) is structurally similar to TCAs and, as such, demonstrates significant anticholinergic side effects. It differs from the TCA amitriptyline by only one double bond.
- Acute recovery phase of myocardial infarction, and patients with arrhythmias, heart block or conduction disturbances, or congestive heart failure.
- All patients suspected of an overdose with FLEXERIL should receive gastrointestinal decontamination.
- You can call (or for the deaf and the hard of hearing) to talk to a pharmacist about your medication questions.
- Many insurance companies require prior authorization for this drug.
- Flexeril is a muscle relaxant and works by blocking the pathways of the neurotransmitters that signal pain.
Cyclobenzaprine reduced or abolished skeletal muscle hyperactivity in several animal models. Animal studies indicate that cyclobenzaprine does not act at the neuromuscular junction or directly on skeletal muscle. Evidence suggests that the net effect of cyclobenzaprine is a reduction of tonic somatic motor activity, influencing both gamma (γ) and alpha (α) motor systems. Abrupt cessation of treatment after prolonged administration rarely may produce nausea, headache, and malaise. This is not a complete list of side effects and others may occur.
Flexeril produces a variety of anticholinergic effects in high doses, altering the activity of brain neurotransmitters. Additionally, Flexeril users may experience mild withdrawal symptoms if the drug is used chronically in high doses. Eight double-blind controlled clinical studies were performed in 642 patients comparing FLEXERIL 10 mg, diazepam, and placebo. Muscle spasm, local pain and tenderness, limitation of motion, and restriction in activities of daily living were evaluated. In three of these studies there was a significantly greater improvement with FLEXERIL than with diazepam, while in the other studies the improvement following both treatments was comparable.
It is not known whether cyclobenzaprine will harm an unborn baby. Flexeril may also be used for purposes not listed in this medication guide.
Seizures should be controlled with benzodiazepines or, if these are ineffective, other anticonvulsants (e.g. phenobarbital, phenytoin). Physostigmine is not recommended except to treat life-threatening symptoms that have been unresponsive to other therapies, and then only in close consultation with a poison control center. Flexeril flexeril tl 177 and Diazepam are both used to treat muscle spasms. They belong to two different drug classes – muscle relaxant and benzodiazepine, respectively. The only salient difference is that Valium has a higher potential to cause drug dependency than Flexeril. However, your physician can better decide which drug is better for your back pain.
Multiple drug ingestion (including alcohol) is common in deliberate cyclobenzaprine overdose. As management of overdose is complex and changing, it is recommended that the physician contact a poison control center for current information on treatment. Signs and symptoms of toxicity may develop rapidly after cyclobenzaprine overdose; therefore, hospital monitoring is required as soon as possible. The acute oral LD50 of FLEXERIL is approximately 338 and 425 mg/kg in mice and rats, respectively.